Author

Stefan Oberlin

University of WürzburgORCID 0000-0003-4577-9946Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:perturbation response prediction· 3 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

Michael T. McManusiD· 3 shared Neil Q. TayiD· 2 shared Ruzbeh MosadeghiiD· 2 shared Albert XueiD· 1 shared Anniina VihervaaraiD· 1 shared Bo HuangiD· 1 shared Caroline C. FriedeliD· 1 shared Cassidy DanykoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMolecular Biology

Michael T. McManusORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintAug 26, 2026

BAF perturbation heightens cancer cell dependence on CDK12-driven transcription elongation by RNA polymerase II

Monika Mačáková, Cassidy Danyko, Stefan Oberlin…·Matjaž Barborič

The paper identifies a co-dependency between CDK12 and the BAF chromatin-remodeling complex in TNBC, showing that their co-inhibition synergistically reduces cancer cell viability.

DOI 10.64898/2026.07.31.742024

humanCRISPR screen

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Molecular BiologyNature MethodsPeer-reviewedMay 25, 2026

Multiplexed Perturbation Enables Scalable Pooled Screens

Stefan Oberlin, Neil Q. Tay, Albert Xue…·Michael T. McManus

This study shows that using multiple guide RNAs in CRISPR screens can reduce cell numbers needed while maintaining screening effectiveness.

3 citations

CRISPR screenexperimental assay

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GenomicsbioRxivPreprintNov 4, 2025

RainBar: Optical Barcoding for Pooled Live-Cell Imaging with Single-Cell Resolution

Ruzbeh Mosadeghi, Daniel A. Foyt, Louis Z. Sharp…·Michael T. McManus

RainBar enables pooled live-cell imaging with single-cell resolution by using optical barcoding to track perturbations and analyze dynamic phenotypes.

DOI 10.1101/2025.11.04.686676

humanimaging

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