Asymmetric induction of IL-23R by CpG and IL-15 in proliferative CLL fractions highlights intraclonal heterogeneity in chronic lymphocytic leukemia
Martina Cardillo, Nadia Bertola, Fabiana Ferrero, Rosanna Massara, Maria Cristina Capra, Daniele Reverberi, Monica Colombo, Antonino Neri, Fortunato Morabito, Franco Fais, Giovanna Cutrona
The paper shows that CpG and IL-15 induce IL-23R in CLL cells, with proliferative subfractions showing higher expression, suggesting a pathogenic mechanism.
bioRxiv · Aug 27, 2025 · PreprintCancer Biology