Guillaume Valentin

This study measures single-cell transcriptional dynamics in zebrafish embryos using MS2-MCP labeling and light sheet microscopy, revealing discrete transcriptional bursts in the segmentation clock.

The paper shows that the regulatory landscape controlling Hoxd gene expression in limbs was co-opted from an ancestral cloacal program in tetrapods.

The paper maps lipid distribution across vertebrate development using mass spectrometry imaging and reveals spatially organized metabolic circuits.

The paper shows that cell-autonomous timing, not cell-extrinsic signals, drives the segmentation clock's wave pattern in vertebrates.