Aurélie Hintermann

The paper shows that the regulatory landscape controlling Hoxd gene expression in limbs was co-opted from an ancestral cloacal program in tetrapods.

This study characterizes the CRY1 R263Q mutation in subterranean animals, showing altered circadian rhythms and gene expression in mice, but no major metabolic defects.

The paper shows that conserved CTCF sites create sequential insulation, controlling the timing of Hox gene activation in pseudo-embryos through chromatin extrusion and cohesin loading.

The paper shows that enhancer function depends on their chromatin context by relocating a distal limb enhancer into a proximal limb TAD, where it loses its distal specificity.

The paper compares Hoxd gene regulation in mammalian vibrissae and avian feather primordia with trunk elongation in mice and chickens, showing lineage-specific enhancer usage and functional divergence in conserved CREs.

The paper identifies POLYCERATE alleles in sheep and goats linked to defective HOXD1 function, showing haploinsufficiency causes horn bud splitting and highlights HOXD1's role in headgear patterning in Bovidae.