Christopher Chase Bolt

CONTEXT-DEPENDENT ENHANCER FUNCTION REVEALED BYTARGETED INTER-TAD RELOCATION

The paper shows that enhancer function depends on their chromatin context by relocating a distal limb enhancer into a proximal limb TAD, where it loses its distal specificity.

MESOMELIC DYSPLASIAS ASSOCIATED WITH THE HOXD LOCUS ARE CAUSED BY REGULATORY REALLOCATIONS

The paper shows that mesomelic dysplasia caused by HOXD locus rearrangements results from ectopic HOXD13 expression due to regulatory reallocations.

DEVELOPMENTAL AND EVOLUTIONARY COMPARATIVE ANALYSIS OF A HOXD REGULATORY LANDSCAPE IN MAMMALS AND BIRDS

The paper compares Hoxd gene regulation in mammalian vibrissae and avian feather primordia with trunk elongation in mice and chickens, showing lineage-specific enhancer usage and functional divergence in conserved CREs.

CONTEXT-INDEPENDENT FUNCTION OF A CHROMATIN BOUNDARY IN VIVO

The paper shows that a chromatin boundary from the HoxD gene cluster can function independently of its genomic context when relocated in mouse development.

SPECIFIC ECTODERMAL ENHANCERS CONTROL THE EXPRESSION OF HoxC GENES IN DEVELOPING MAMMALIAN INTEGUMENTS

This study identifies two mammalian-specific enhancers upstream of the HoxC gene cluster that regulate Hoxc gene expression in ectodermal organs like hair and nails.

A Complex Regulatory Landscape Involved In The Development Of External Genitals

The paper investigates how regulatory landscapes around the HoxD gene cluster are formed and function, finding that individual sequence deletions have minimal impact on transcription.

CONSERVATION AND VARIATIONS OF BIMODAL HoxD GENE REGULATION DURING TETRAPOD LIMB DEVELOPMENT

The paper compares bimodal HoxD gene regulation in chicken and mouse limb development, finding conserved mechanisms with species-specific differences in enhancer activity and TAD boundaries.