Yating Liu

The paper screens 5'UTR mutations in neurodevelopmental disorder genes to identify functional variants impacting translation and protein production, finding some mutations affect known syndromic autism genes in neurons.

This paper develops a MYT1L syndrome mouse model that recapitulates human phenotypes, revealing disrupted brain development and neuronal maturation as underlying mechanisms.

utR.annotation annotates genomic variants in UTR regions to assess their potential impact on post-transcriptional regulation in human and mouse species.

The paper shows that microglia perform local protein synthesis in peripheral processes to support phagocytic activity and lysosomal machinery assembly.

This study identifies CELF6 mRNA targets using CLIP-Seq and shows CELF6 represses synaptic gene translation by reducing RNA abundance through UGU-rich motifs, extending its known role beyond splicing.

The paper uses TRAP to analyze allelic translation efficiency imbalance in mouse astrocytes, finding that some genetic variants affect ribosome occupancy independently of transcript abundance.

This study identifies genomic binding sites of Gtf2i and Gtf2ird1 in the developing brain and assesses their combined effects on transcription and behavior in knockout mice.

The paper uses CRISPR TRAPseq to show QKI is important for astrocytic maturation and synaptic control in vivo.

G-OnRamp provides a web-based platform for collaborative genome annotation using UCSC Assembly Hubs and JBrowse/Apollo browsers with various evidence tracks.