TREM2+ macrophages accumulate in alveoli of human pulmonary tuberculosis providing a permissive niche for bacterial growth
Rosane M. B. Teles, Chaouki Benabdessalem, Jonathan Perrie, Cenfu Wei, Julie West, Bruno Jorge de Andrade Silva, Priscila Ribeiro Andrade, Lilah A. Mansky, Prajan Divakar, Linda A. Fischbacher, Karen Lam, Feyiang Ma, Yiqian Gu, Kimia Rategh, Madeline Brown, , Robert L. Modlin
This study identifies TREM2+ lipid-laden macrophages in alveolar TB pneumonia that support Mtb survival, contrasting with granulomas, and shows pharmacological reversal of this immunometabolic state.
bioRxiv · Jul 15, 2025 · PreprintImmunology