Author

Alexander Klotz

University of BaselORCID 0000-0003-4666-8607Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Andreas KaczmarczykiD· 2 shared Urs JenaliD· 2 shared Alejandro Tejada-ArranziD· 1 shared Annika Plack· 1 shared Marek BasleriD· 1 shared Minia Antelo-VarelaiD· 1 shared Pablo ManfrediiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

Andreas KaczmarczykORCID

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2 papers

Recent·Most cited

Mechanisms of P. aeruginosa resistance to Type VI Secretion System attacks

Alejandro Tejada-Arranz, Annika Plack, Minia Antelo-Varela, Andreas Kaczmarczyk, Alexander Klotz, Urs Jenal, Marek Basler

This study identifies pathways in P. aeruginosa that confer resistance to T6SS effectors from Acinetobacter baylyi and Vibrio cholerae, revealing links between T6SS resistance and antibiotic susceptibility.

Nature Communications · Nov 28, 2025Peer-reviewedMicrobiology

Genome-wide high-density CRISPR interference screens reveal condition-specific metabolic vulnerabilities in Pseudomonas aeruginosa PAO1

Andreas Kaczmarczyk, Alexander Klotz, Pablo Manfredi, Urs Jenal

The paper uses CRISPRi screens to identify metabolic vulnerabilities in P. aeruginosa PAO1 under different conditions, revealing key genes for targeting chronic infections.

bioRxiv · Aug 12, 2025 · PreprintMicrobiology