Marek Basler

This study develops LiFEx to correlate live-cell imaging with expansion microscopy, revealing membrane changes linked to bacterial dissemination.

This study identifies distinct subpopulations of Pseudomonas aeruginosa that use different virulence factors to cause tissue damage during infection.

This study shows that intracellular pathogens like Burkholderia thailandensis and Shigella flexneri can enter host nuclei via actin tail motility, forming a protective niche in mitotically active cells.

The paper investigates how resistance to T6SS toxins evolves, finding toxin-specific resistance mechanisms and trade-offs in E. coli.

This study shows Burkholderia thailandensis switches from T6SS-1 to T6SS-5 during phagosomal maturation, controlled by the VirAG two-component system.

This study shows marine bacteria use T6SS to compete in liquid by aggregating via adhesins, challenging the assumption that T6SS activity is limited to solid surfaces.

This study identifies TagF as a checkpoint protein that coordinates spike-loading in T6SS assembly by preventing premature sheath formation and interacting with Hcp and TagZ.

This study identifies pathways in P. aeruginosa that confer resistance to T6SS effectors from Acinetobacter baylyi and Vibrio cholerae, revealing links between T6SS resistance and antibiotic susceptibility.

The paper shows bacteria use contact-dependent antagonism to acquire nutrients by lysing neighbors during starvation, enhancing growth in spatially structured environments.

This study shows that multiple toxins in T6SS limit resistance evolution in bacteria, similar to combination therapies in medicine.

reComBat removes batch effects from large-scale, multi-source omics data while preserving biological variation, outperforming existing methods for public gene expression data of Pseudomonas aeruginosa.

This study shows that modifications to VipA and VipB proteins prevent T6SS sheath contraction and effector delivery.