Pradip Sinha

SARS-CoV-2 PLpro Hijacks a Conserved Stress Signaling Network to Drive Organ-Specific Loss of Epithelial Homeostasis

This paper identifies SARS-CoV-2 PLpro as a driver of epithelial stress and tissue damage across species by activating metabolic and inflammatory pathways in Drosophila and mammalian models.

RasG12V Oncogene-Induced Epithelial Senescence and Its Relay Promotes Host Metabolic Syndrome in Drosophila

This study shows that RasG12V-induced epithelial senescence in Drosophila triggers host metabolic syndrome through cytokine signaling, linking oncogene-induced senescence to metabolic disorders.

Paradoxical Tumor Suppressor Role of Yorkie Through a TOR-Dependent α-Tubulin Acetylation in Select Squamous Epithelium

The paper shows that Yorkie acts as a tumor suppressor in Drosophila squamous epithelia by suppressing TOR-driven α-tubulin acetylation, which is tissue-specific and distinct from other epithelial lineages.

Human ERG Oncoprotein Represses Chip/LDB1 LIM-Domain Binding Gene in Drosophila

The paper shows human ERG oncoprotein represses the LIM-domain binding gene Chip/LDB1 in Drosophila, with implications for prostate cancer, through histone modification and disruption of the Chip-Tailup complex.

Degenerating Drosophila Larval Epidermal Cells Drive Thorax Closure

The paper shows that degenerating larval epidermal cells generate pull forces that drive thorax closure in Drosophila by contracting and shrinking, facilitating HE migration and zipping.

Drosophila Male Accessory Gland Displays Developmental Ground Plan of a Primitive Prostate

The paper shows that Drosophila male accessory gland shares developmental genetic toolkits with mammalian prostate, revealing deep homology.