Aaron J. Grossberg

This study identifies impaired adipose anabolism in pancreatic cancer cachexia and shows that HuR inhibition restores adipose anabolism in mice.

This study shows that IL-6 enhances T cell-mediated anti-tumor immunity in pancreatic cancer by increasing lymphoid aggregates, CD4 T cells, and reducing Tregs.

This study shows that HuR promotes immune evasion in PDAC by inhibiting T cell infiltration and function, suggesting HuR as a therapeutic target with immunotherapy.

This study shows that TCMCB07, a melanocortin-4 receptor antagonist, reduces chemotherapy-induced anorexia and weight loss in rat models.