Zhiqiang Yan

The paper identifies TMC3-8 as mechanosensitive ion channels by showing their plasma membrane localization and stretch-activated currents in cultured cells.

This study identifies TMEM63B as a mammalian thirst receptor in the subfornical organ, showing it mediates osmotic and dehydration-induced thirst through ion channel activity.

This study identifies the role of the fourth transmembrane domain in TRAAK channel mechanosensitivity through chimeric mutations and functional analysis.

The paper presents the cryo-EM structure of the human LRRC8A protein, revealing its trimer-of-dimers assembly and structural features relevant to its function as a volume-regulated anion channel.