Cell BiologybioRxivPreprint
NAADP elicits two-pore channel currents by lifting Lsm12-mediated inhibition of PI(3,5)P2 activation
Xin Guan, Canwei Du, Kunal R. Shah, Jiusheng Yan
This study shows NAADP reverses Lsm12 inhibition of PI(3,5)P2-dependent TPC activation, enabling Ca2+ release from acidic organelles.
DOI 10.64898/2026.04.13.718294