Troy Ketela

The paper constructs a single-nucleus transcriptome atlas of the orbitofrontal cortex in ALS and identifies cell-type-specific transcriptional changes, introducing a deep learning model to analyze alternative polyadenylation.

The paper constructs a molecular atlas of the human brain vasculature using single-cell RNA sequencing, revealing molecular heterogeneity and disease-related alterations in vascular cells.

This study benchmarks four methods for assigning cell type labels to cell clusters in scRNA-seq data, showing high performance but variability in precision-recall across methods and datasets.