Author

Aiden M. Sababi

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 4 Research Focus:differential expression· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Hani GoodarziiD· 3 shared Gary D. BaderiD· 2 shared Albertas NavickasiD· 1 shared Alice Huang· 1 shared Amir Momen-RoknabadiiD· 1 shared Anna V. Hartwig· 1 shared Babak AlipanahiiD· 1 shared Babak BehsaziD· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBioinformatics

Hani GoodarziORCID

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Author profile →

4 papers

Recent·Most cited

A multi-modal cell-free RNA language model for liquid biopsy applications

Mehran Karimzadeh, Aiden M. Sababi, Amir Momen-Roknabadi, Nae-Chyun Chen, Taylor B. Cavazos, Sukh Sekhon, Jieyang Wang, Rose Hanna, Alice Huang, Dang Le Tri Nguyen, Selina Chen, Ti Lam, Kimberly H. Chau, Anna V. Hartwig, Lisa Fish, , Hani Goodarzi

Exai-1 is a transformer-based model that integrates RNA sequence and expression data to improve cfRNA analysis for disease detection.

Nature Machine Intelligence · Dec 10, 2025Peer-reviewedBioinformatics

Single-nucleus transcriptome atlas of orbitofrontal cortex in amyotrophic lateral sclerosis with a deep learning-based decoding of alternative polyadenylation mechanisms

Paul M. McKeever, Aiden M. Sababi, Raghav Sharma, Zhiyu Xu, Shangxi Xiao, Philip McGoldrick, Troy Ketela, Christine Sato, Danielle Moreno, Naomi P. Visanji, Gábor Géza Kovács, Julia Lee Keith, Lorne H. Zinman, Ekaterina A. Rogaeva, Hani Goodarzi, , Janice Robertson

The paper constructs a single-nucleus transcriptome atlas of the orbitofrontal cortex in ALS and identifies cell-type-specific transcriptional changes, introducing a deep learning model to analyze alternative polyadenylation.

Cell Genomics · Sep 17, 2025Peer-reviewedNeuroscience

Decoy-seq unlocks scalable genetic screening for regulatory small noncoding RNAs

Bong Gun Choi, Sushil Sobti, Larisa M. Soto, Trey Charbonneau, Aiden M. Sababi, Albertas Navickas, Hamed Shateri Najafabadi, Hani Goodarzi

Decoy-seq enables single-cell perturbation screening of small noncoding RNAs by using TuD decoys to inhibit smRNAs, revealing their regulatory roles in cancer.

bioRxiv · Jan 25, 2025 · PreprintSystems Biology

PRMT5 is required for full-length HTT expression by repressing multiple proximal intronic polyadenylation sites

Mona Alqazzaz, Felipe E. Ciamponi, Jolene Caifeng Ho, Maxim I. Maron, Manisha Yadav, Aiden M. Sababi, Graham Dickson and Hugh MacLeod, Moloud Ahmadi, Garrett Bullivant, Vincent Tano, Sarah R. Langley, María Sánchez‐Osuna, Patty Sachamitr, Michelle M. Kushida, Laura M. Richards, , Panagiotis Prinos

This paper identifies PRMT5 as a regulator of HTT mRNA splicing and alternative polyadenylation, showing that its inhibition reduces full-length HTT protein levels by promoting premature termination and cleavage.

bioRxiv · Mar 14, 2024 · PreprintNeuroscience