Louise A C Millard

This study uses Mendelian randomization to identify causal risk factors for Alzheimer's disease, finding that education, fluid intelligence, and physical activity are likely causal, while most associations are consequences of early disease.

The paper develops a variance prioritisation method to detect gene-interaction effects on blood biomarker concentrations using UK Biobank data, identifying novel gene-environment and gene-gene interactions.

PhenoSpD estimates phenotypic correlations and corrects multiple testing using GWAS summary statistics, reducing dimensionality for complex traits.