Laxmi Bhatta

Investigating adiposity in childhood and adulthood on later life sleep health: a lifecourse Mendelian randomization study

This study uses Mendelian randomization to examine the lifecourse effects of childhood and adulthood adiposity on sleep health outcomes, finding that adult adiposity is a risk factor for insomnia while childhood adiposity may have protective effects when maintained in adulthood.

Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity

Associations between common genetic variants and income provide insights about the socioeconomic health gradient

This study identifies genetic variants associated with income and shows they correlate with health outcomes and educational attainment.

Genome-wide association study of placental weight in 179,025 children and parents reveals distinct and shared genetic influences between placental and fetal growth

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

Investigating the causal effects of childhood and adulthood adiposity on later life mental health outcome: a Mendelian randomisation study

This study uses Mendelian randomization to examine the causal effects of childhood and adulthood adiposity on anxiety and depression, finding childhood adiposity may protect against mental health issues if obesity is absent in adulthood.

Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

This study performs a multi-ancestry GWAS on lung function and COPD, identifying 559 genes and 29 pathways, and showing genetic risk scores are associated with COPD across ancestries.

Global biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

This study evaluates polygenic risk score methods across diverse biobanks and ancestries, finding that European reference panels often yield better performance, while PRS-CS outperforms P+T for high-heritability traits.

Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases

This paper uses proteome-wide Mendelian randomization across multiple ancestries to identify causal protein-disease associations and drug targets in over 1.26 million individuals.

The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization

This study uses Mendelian randomization to identify causal risk factors for Alzheimer's disease, finding that education, fluid intelligence, and physical activity are likely causal, while most associations are consequences of early disease.

Trans-ancestry meta-analysis improves performance of genetic scores for multiple adiposity-related traits in East Asian populations

This paper improves genetic scores for adiposity traits in East Asian populations by using trans-ancestry meta-analysis, increasing variance explained compared to European-derived scores.

Multi-ancestry GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish

This study conducts a multi-ancestry GWAS for venous thromboembolism, identifies novel loci, and validates their function in zebrafish.