Juan Ernesto Ludert

This study shows that dengue virus NS1 partially translocates to the nucleus, modulating host transcription and supporting viral replication.

This study shows that dengue virus NS1 protein increases Aedes aegypti midgut permeability and promotes virus dissemination by disrupting epithelial junctions and inhibiting metalloproteinase expression.

This study identifies KLC1 as a host susceptibility factor for dengue virus in mosquito cells by showing its interaction with NS1 and role in lipid droplet homeostasis.

This study identifies a caveolin binding domain in dengue and Zika virus NS1 that determines their unconventional secretion pathway in mosquito cells, distinguishing them from other flaviviruses.