Yi Sheng

The paper validates three TEX11 variants associated with human azoospermia by generating mouse models and observing fertility and spermatogenesis defects.

This study shows that protamine PTMs create heterogeneous chromatin states in sperm, affecting fertility and chromatin integrity.

This paper describes a mouse model with a human ADAR G1007R mutation that causes neuroinflammation and shows that deleting MDA5 can reverse brain inflammation.

This study shows that the microbiota influences reproductive lifespan by maintaining the ovarian reserve through short chain fatty acids and gene regulatory networks.