Author

Qingde Wang

University of PittsburghORCID 0000-0002-2482-7972Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Xinfeng GuoiD· 2 shared Adam P. WilliamsoniD· 1 shared Bilal Elfayoumi· 1 shared Brian Temsamrit· 1 shared Carleigh A O'BrieniD· 1 shared Chaowei ShangiD· 1 shared Chet Huan OoniD· 1 shared Christoph A. ThaissiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Xinfeng GuoORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutieres Syndrome neuropathology

Kelsey Marie Nemec, Genevieve Gucci Grace Capispisan Uy, V Sai Chaluvadi, Freddy S Purnell, Bilal Elfayoumi, Leila Byerly, Micaela L O'Reilly, Carleigh A O'Brien, William H. Aisenberg, Sonia I Lombroso, Xinfeng Guo, Niklas Blank, Chet Huan Oon, Fazeela Yaqoob, Brian Temsamrit, , F. Chris Bennett

This study introduces ER-Hoxb8 macrophages as a model for microglia replacement and uses them to study the role of Adar1 mutations in Aicardi-Goutieres Syndrome.

eLife · Jan 27, 2026Peer-reviewedNeuroscience

Aicardi-Goutieres Syndrome Associated ADAR G1007R mutation dominantly induces neuroinflammation in mouse brain

Xinfeng Guo, Jiajun Liu, Chaowei Shang, Christopher J. Guerriero, Clayton A. Wiley, Richard A. Steinman, Yi Sheng, Jeffrey L. Brodsky, Timothy R. Billiar, Silvia Liu, Qingde Wang

This paper describes a mouse model with a human ADAR G1007R mutation that causes neuroinflammation and shows that deleting MDA5 can reverse brain inflammation.

bioRxiv · Apr 21, 2025 · PreprintNeuroscience