Author

Alisha M. Gruntman

Tufts UniversityORCID 0000-0003-4818-8391Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:variant calling· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

April Destefano· 2 shared Guangping GaoiD· 2 shared Terence R. FlotteiD· 2 shared Chunwei ZhengiD· 1 shared Dan WangiD· 1 shared Darcy Reil· 1 shared Debora Pires-FerreiraiD· 1 shared Erik J. SontheimeriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

April Destefano

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Molecular BiologyPLoS PathogensPeer-reviewedSep 17, 2025

A single amino acid variant in the variable region I of AAV capsid confers liver detargeting

Ruxiao Xing, Mengyao Xu, Darcy Reil…·Dan Wang

The paper identifies an amino acid variant in AAV capsid VR-1 that reduces liver targeting, suggesting its potential for minimizing liver toxicity in gene therapy.

8 citationstop 4%

mouseDNA methylation

𝕏 PostBluesky

BioengineeringMolecular TherapyPeer-reviewedAug 28, 2025

A Compact Base Editor Rescues AATD-associated Liver and Lung Disease in Mouse Models

Jenny Gao, Nathan Bamidele, Debora Pires-Ferreira…·Wen Xue

This paper demonstrates that a compact ABE corrects the PiZ mutation in AATD mouse models, reducing liver disease and improving lung function.

4 citations

mouseCRISPR screen

𝕏 PostBluesky