Dan Wang

Host genetic regulation of fermentation-related cecal microbial taxa is associated with loin muscle deposition in meat rabbits

The paper identifies host genetic and microbial factors associated with loin muscle weight in meat rabbits, finding links between cecal microbiota and host genes.

Exacerbation of a Subset of Behavioral Phenotypes by Early Treatment with AAV FOXG1 Gene Replacement Therapy in a Mouse Model of FOXG1 Syndrome

This study shows that early AAV FOXG1 gene therapy in female mice worsens motor behaviors, while it benefits males, highlighting gender-specific risks in potential human treatments.

A single amino acid variant in the variable region I of AAV capsid confers liver detargeting

The paper identifies an amino acid variant in AAV capsid VR-1 that reduces liver targeting, suggesting its potential for minimizing liver toxicity in gene therapy.

Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice

This paper shows that gene therapies can reduce absence seizures in DBA/2J mice with Scn2a deficiency by restoring NaV1.2 or introducing human KV1.1.

Behavioral Efficacy of AAV FOXG1 Gene Replacement Therapy in a Mouse Model of FOXG1 Syndrome

This study shows that AAV FOXG1 gene therapy improves behavioral deficits in a mouse model of FOXG1 syndrome with a Q84P mutation.

A Comprehensive Atlas of AAV Tropism in the Mouse

This paper maps the tissue tropism of ten AAV serotypes in mice after systemic delivery, identifying liver preference and unexpected transduction in adrenals, testes, and ovaries.

PAMPHLET: A Robust Toolkit for Precise PAM Prediction and Unveiling PAM Consistency in Highly Co-occurrence CRISPR-Cas Systems

PAMPHLET predicts PAM sequences for CRISPR-Cas systems by expanding spacer data through homology searches, achieving high accuracy validated by experimental methods.

Whole-genome resequencing revealed the Origin and Domestication of Chinese Domestic Rabbits

This study uses whole-genome resequencing to trace the origin and domestication of Chinese domestic rabbits, identifying genetic adaptations and multiple potential origins.

CRISPR-Detector: Fast and Accurate Detection, Visualization, and Annotation of Genome-Wide Mutations Induced by Gene Editing Events

CRISPR-Detector detects, visualizes, and annotates genome-wide mutations from CRISPR/Cas gene editing events with improved speed, scalability, and accuracy.

Cost-effectively dissecting the genetic architecture of complex wool traits in rabbits by low-coverage sequencing

This study uses low-coverage sequencing and imputation to identify QTLs for wool traits in rabbits, finding six QTLs with phenotypic contributions up to 7.50%.

X chromosome factor Kdm6a enhances memory independent of its demethylase function in the aging XY male brain

The paper shows that increasing Kdm6a in aging male mice improves memory without needing its demethylase function.

An Improved Linear Mixed Model for Multivariate Genome-Wide Association Studies

This paper introduces an improved linear mixed model for multivariate genome-wide association studies that handles incomplete data and reduces computational complexity.

Linkage disequilibrium under polysomic inheritance

This paper extends linkage disequilibrium measures to polysomic inheritance and evaluates their statistical performance under different mating systems.

Precision Cas9 Genome Editing in vivo with All-in-one, Self-targeting AAV Vectors

This paper develops single-AAV vectors for precise in vivo genome editing using Nme2Cas9 with HDR templates or multiple sgRNAs, showing efficacy in treating HT-I and MPS-I mouse models.

DNB-Based On-Chip Motif Finding (DocMF): a High-Throughput Method to Profile Different Types of Protein-DNA Interactions

The paper introduces DocMF, a high-throughput method to profile protein-DNA interactions, identifying PAM sequences for CRISPR systems and other DNA-binding proteins.

Rapid Epistatic Mixed Model Association Studies by Controlling Multiple Polygenic Effects

The paper introduces a rapid mixed model for genome-wide epistatic association analysis that handles multiple polygenic effects and demonstrates its efficiency on yeast and human datasets.

Selective targeting of an oncogenic KRAS mutant allele by CRISPR/Cas9 induces efficient tumor regression

This paper develops CRISPR systems to target and deplete an oncogenic KRAS mutant allele, leading to tumor regression in vitro and in vivo.

Enhance genome editing efficiency and specificity by a quick CRISPR/Cas9 system

This study introduces qCas9, a modified CRISPR/Cas9 system that enhances genome editing efficiency and reduces off-target effects in zebrafish and mammalian cells.

Efficient Multivariate Analysis Algorithms for Longitudinal Genome-wide Association Studies

The paper develops efficient multivariate association algorithms for longitudinal GWAS, improving statistical power and computational speed for analyzing large-scale longitudinal data.