Author

Jenny Gao

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:variant calling· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:mouse· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Erik J. SontheimeriD· 2 shared Haoyang ChengiD· 2 shared Wen XueiD· 2 shared Alisha M. GruntmaniD· 1 shared Andrew PettiiD· 1 shared April Destefano· 1 shared Bin LiuiD· 1 shared Chunwei ZhengiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Erik J. SontheimerORCID

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2 papers

Recent·Most cited

Prime assembly with linear DNA donors enables large genomic insertions

Bin Liu, Andrew Petti, Xuntao Zhou, Haoyang Cheng, Jenny Gao, Matthew Yee, Youwei Qiao, Yanjun Zhang, Lin Mei Zhou, Scot A. Wolfe, Tingting Jiang, Erik J. Sontheimer, Wen Xue

This paper introduces a Prime Assembly method for inserting large DNA fragments into the genome, achieving efficient and precise insertions up to 11 kilobase pairs.

Nature · Apr 29, 2026Peer-reviewedBiochemistry

A Compact Base Editor Rescues AATD-associated Liver and Lung Disease in Mouse Models

Jenny Gao, Nathan Bamidele, Debora Pires-Ferreira, Chunwei Zheng, April Destefano, Haoyang Cheng, Qiushi Tang, Yueying Cao, Jun Xie, Guangping Gao, Alisha M. Gruntman, Erik J. Sontheimer, Terence R. Flotte, Wen Xue

This paper demonstrates that a compact ABE corrects the PiZ mutation in AATD mouse models, reducing liver disease and improving lung function.

Molecular Therapy · Aug 28, 2025Peer-reviewedBioengineering