Anna‐Lena Neehus

Single-cell multiomic mapping of genetic predisposition to childhood B-cell acute lymphoblastic leukemia

The paper uses single-cell multiomic analysis to identify genetic variants and regulatory disruptions linked to childhood B-cell acute lymphoblastic leukemia.

A functional genomics screen of human B-cell differentiation reveals convergent mechanisms of inherited childhood leukemia predisposition

The paper uses CRISPR and single-cell transcriptomics to study how inherited variants in B-cell development contribute to childhood leukemia.

Mapping genetic risk mechanisms for immune-mediated diseases across human dendritic cell differentiation

This study maps genetic risk mechanisms for immune-mediated diseases by integrating single-cell multi-omic data with fine-mapped variants from genome-wide association studies.

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation

The paper identifies a genetic variant that protects against clonal hematopoiesis by regulating RNA-binding protein MSI2 in hematopoietic stem cells.

Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense

This study investigates itaconate's role in human macrophages, showing distinct effects in alveolar-like and M-CSF-derived macrophages during M. tuberculosis infection.

Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

This study uses ancient genomics to show that genetic adaptation to pathogens in post-Neolithic Europe increased inflammatory disease risk through antagonistic pleiotropy.