Cleber Camilo Melo-Filho

This paper identifies broad-spectrum filovirus inhibitors using computational screening and validates them against multiple viral species, finding synergistic compound pairs effective against Ebola and Marburg viruses.

This study identifies conserved binding sites in filovirus proteins to guide the development of broad-spectrum antivirals, finding high conservation in L and VP40 proteins and validating existing drugs like Remdesivir.

The paper uses machine learning to identify novel HDAC6/AKT2 inhibitors for myeloid cancer treatment, finding compounds with potent anticancer activity.

The paper curates a database of antiviral compounds tested against 13 emerging viruses, identifies potential broad-spectrum antivirals, and highlights the need for coordinated research efforts.

The paper identifies five compounds that inhibit SARS-CoV-2 replication by binding to ACE2 without disrupting its enzymatic function, serving as potential acute treatments for COVID-19.