Author

Vijay Kumar Singh

Harvard UniversityORCID 0000-0003-4872-4545Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Arijit ChakrabortyiD· 3 shared Laurence G. RahmeiD· 3 shared A. Aria TzikaiD· 2 shared Shifu AggarwaliD· 2 shared Sujin Cha· 2 shared Alexandra DimitriouiD· 1 shared Arunava Bandyopadhaya· 1 shared Claire de CrescenzoiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Arijit ChakrabortyORCID

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3 papers

Recent·Most cited

Molecular BiologyFrontiers in ImmunologyPeer-reviewedJul 15, 2025

Revealing the impact of Pseudomonas aeruginosa quorum sensing molecule 2'-aminoacetophenone on human bronchial-airway epithelium and pulmonary endothelium using a human airway-on-a-chip

Shifu Aggarwal, Arijit Chakraborty, Vijay Kumar Singh…·Laurence G. Rahme

This study investigates the effects of 2'-aminoacetophenone on human bronchial-airway epithelium and pulmonary endothelium using an airway-on-a-chip model, revealing differential pathway regulation and potential therapeutic implications.

5 citations

humanbulk RNA-seq

ImmunologyeLifePeer-reviewedJun 12, 2024

The Bacterial Quorum-Sensing Signal 2-Aminoacetophenone Rewires Immune Cell Bioenergetics through the PGC-1α/ERRα Axis to Mediate Tolerance to Infection

Arijit Chakraborty, Arunava Bandyopadhaya, Vijay Kumar Singh…·Laurence G. Rahme

This study shows that the bacterial QS signal 2-AA modulates immune cell bioenergetics via the PGC-1α/ERRα axis, promoting immune tolerance and pathogen persistence.

13 citations

mouseproteomics

MicrobiologymBioPeer-reviewedJun 11, 2024

Skeletal Muscle Mitochondrial Dysfunction Mediated by Pseudomonas aeruginosa Quorum Sensing Transcription Factor MvfR: Reversing Effects with Anti-MvfR and Mitochondrial-Targeted Compounds

Shifu Aggarwal, Vijay Kumar Singh, Arijit Chakraborty…·Laurence G. Rahme

This study investigates how Pseudomonas aeruginosa's MvfR quorum sensing transcription factor disrupts mitochondrial function in skeletal muscle and shows that inhibiting MvfR or using mitochondrial-targeted compounds can reverse these effects.

6 citations

mouseATAC-seq