Laurence G. Rahme

Revealing the impact of Pseudomonas aeruginosa quorum sensing molecule 2'-aminoacetophenone on human bronchial-airway epithelium and pulmonary endothelium using a human airway-on-a-chip

This study investigates the effects of 2'-aminoacetophenone on human bronchial-airway epithelium and pulmonary endothelium using an airway-on-a-chip model, revealing differential pathway regulation and potential therapeutic implications.

MvfR shapes Pseudomonas aeruginosa Interactions in Polymicrobial Contexts: Implications for Targeted Quorum Sensing Inhibition

This study shows that inhibiting MvfR in Pseudomonas aeruginosa reduces its competitive advantage against other pathogens and decreases its virulence.

The L-lactate dehydrogenases of Pseudomonas aeruginosa are conditionally regulated but both contribute to survival during macrophage infection

This paper investigates the regulation and role of L-lactate dehydrogenases LldD and LldA in Pseudomonas aeruginosa, showing they are conditionally expressed and contribute to survival during macrophage infection.

The Bacterial Quorum-Sensing Signal 2-Aminoacetophenone Rewires Immune Cell Bioenergetics through the PGC-1α/ERRα Axis to Mediate Tolerance to Infection

This study shows that the bacterial QS signal 2-AA modulates immune cell bioenergetics via the PGC-1α/ERRα axis, promoting immune tolerance and pathogen persistence.

Skeletal Muscle Mitochondrial Dysfunction Mediated by Pseudomonas aeruginosa Quorum Sensing Transcription Factor MvfR: Reversing Effects with Anti-MvfR and Mitochondrial-Targeted Compounds

This study investigates how Pseudomonas aeruginosa's MvfR quorum sensing transcription factor disrupts mitochondrial function in skeletal muscle and shows that inhibiting MvfR or using mitochondrial-targeted compounds can reverse these effects.

Evidence for a bacterial Lands cycle phospholipase A: Structural and mechanistic insights into membrane phospholipid remodeling

This paper identifies PlaF, a bacterial phospholipase A1 involved in GPL remodeling, and characterizes its structure and mechanism of dimerization-mediated inactivation.