Author

Michael J. Therien

Duke UniversityORCID 0000-0003-4876-0036Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

James A. WellsiD· 2 shared William F. DeGradoiD· 2 shared Zhi LiniD· 2 shared Danielle L. SwaneyiD· 1 shared Ian J. BakanasiD· 1 shared Jarrett P. ManserghiD· 1 shared Jiaqi ZhuiD· 1 shared Mark J. S. KellyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

James A. WellsORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 23, 2026

A de novo designed enzyme for photo-proximity labeling of E3 ligase neighborhoods in live cells

Nam Hyeong Kim, Zhi Lin, Sangwon Nam…·James A. Wells

This paper introduces EYClamp, a de novo designed enzyme for photo-proximity labeling of E3 ligase neighborhoods in live cells, identifying over 1,500 candidate neighbors for four E3 ligases.

DOI 10.64898/2026.07.22.739993

proteomicsexperimental assay

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BiophysicsJournal of the American Chemical SocietyPeer-reviewedFeb 21, 2025

De novo design of proteins that bind naphthalenediimides, powerful photooxidants with tunable photophysical properties

Samuel I. Mann, Zhi Lin, Sophia K. Tan…·William F. DeGrado

This paper designs a protein to bind naphthalenediimides and evaluates its ability to generate reactive species for proximity labeling.

13 citations

protein structuredeep learning

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