Nam Hyeong Kim

This paper demonstrates that large language models can generate de novo protein sequences that bind specific ligands without copying existing sequences, with a 25% hit rate in experimental validation.

This paper introduces EYClamp, a de novo designed enzyme for photo-proximity labeling of E3 ligase neighborhoods in live cells, identifying over 1,500 candidate neighbors for four E3 ligases.

An all-atom diffusion model unifying biomolecular structure prediction and sequence-structure generation designs experimentally validated nanobodies, mini-proteins, and linear or cyclic peptides across 26 diverse targets.