Xinli Hu

This study identifies glycophagy dysregulation as a mechanism of diabetic heart disease and shows that Gabarapl1 gene therapy improves cardiac function in diabetic mice and human cardiac organoids.

The paper introduces DQmB-HA, a method for sensitive quantification of carboxylic acid metabolites, enabling single-cell analysis and blood sample profiling in mice and humans.

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.