Author

Upasna Varma

The University of Melbourne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

DAVID J. TAYLORiD· 3 shared James R. BelliD· 3 shared Kimberley M. MelloriD· 3 shared Lea M.D. DelbridgeiD· 3 shared Lorna J. DanielsiD· 3 shared Marco AnnandaleiD· 3 shared Parisa KoutsifeliiD· 3 shared Roberta A. GottliebiD· 3 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

DAVID J. TAYLORORCID

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3 papers

Recent·Most cited

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues

Kimberley M. Mellor, Upasna Varma, Parisa Koutsifeli, Claire L. Curl, Johannes V. Janssens, Lorna J. Daniels, Gabriel B. Bernasochi, Antonia J. A. Raaijmakers, Marco Annandale, X. Li, Samuel L. James, DAVID J. TAYLOR, Koen Raedschelders, Kate L. Weeks, Richard J. Mills, , Lea M.D. Delbridge

This study identifies glycophagy dysregulation as a mechanism of diabetic heart disease and shows that Gabarapl1 gene therapy improves cardiac function in diabetic mice and human cardiac organoids.

Nature Cardiovascular Research · Sep 29, 2025Peer-reviewedPhysiology

Methods for detection of cardiac glycogen-autophagy

Parisa Koutsifeli, Lorna J. Daniels, Joshua P. H. Neale, Sarah Fong, Upasna Varma, Marco Annandale, Xun Li, Yohanes N. S. Nursalim, James R. Bell, Kate L. Weeks, Aleksandr B. Stotland, DAVID J. TAYLOR, Roberta A. Gottlieb, Lea M.D. Delbridge, Kimberley M. Mellor

The paper develops methods to detect glycophagy in cardiac cells using antibodies and fluorescent markers to measure lysosomal flux and glycogen accumulation.

Autophagy Reports · Sep 22, 2024Peer-reviewedMolecular Biology

Protective role of the Atg8 1 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease

Kimberley M. Mellor, Upasna Varma, Parisa Koutsifeli, Claire L. Curl, Johannes V. Janssens, Lorna J. Daniels, Gabriel B. Bernasochi, Antonia J. A. Raaijmakers, Victoria L. Benson, E. Chan, Marco Annandale, Xun Li, Yohanes N. S. Nursalim, Wendy T.K. Ip, David J. Taylor, , Lea M.D. Delbridge

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.

bioRxiv · Jun 21, 2021 · PreprintMolecular Biology