Si Fang

This study identifies nine glucose-lowering drug targets with anti-aging potential mediated by DNA methylation in specific tissues using multi-omics genetic methods.

This paper investigates the causal effect of puberty timing on plasma metabolites using Mendelian randomization and finds moderate evidence of causal relationships for 16 metabolites after adjusting for confounders.

The paper constructs an atlas linking 129 polygenic risk scores to 249 metabolites in 83,004 UK Biobank participants, finding associations with BMI and smoking liability on systemic inflammation.

This paper evaluates block jackknife resampling in Mendelian randomization to reduce overfitting bias from overlapping samples, showing it outperforms external GWAS and overlapping sample methods in robustness.

This paper identifies 29 metabolites associated with genetic predisposition to higher BMI using a recall-by-genotype study design in young adults.