Laura J. Corbin

The paper updates the metaboprep R package to support proteomics data, enhancing its utility for multi-omics preprocessing in epidemiological research.

This paper identifies 29 metabolites associated with genetic predisposition to higher BMI using a recall-by-genotype study design in young adults.

metaboprep provides an R package for standardized pre-analysis processing and reporting of metabolomics data, enabling quality assessment and sample/metabolite selection.

This study examines how a schizophrenia-associated ZNF804A variant affects sleep neurophysiology and memory consolidation in healthy adults.

The paper identifies the prevalence and phenotypic impact of loss of function mutations in the MC4R gene in a UK birth cohort, finding a 0.30% carrier rate with significant effects on body weight and BMI.

This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.

The paper examines geographical stratification of genetic variants in UK Biobank data and its impact on genetic association analyses, finding that genetic risk scores show geographic structure and may introduce bias.

This paper estimates narrow-sense heritability using identity-by-descent information in unrelated individuals and finds that IBD-based methods can capture rare variant contributions but are affected by stratification.

This paper introduces the Recall-by-Genotype study design to improve causal inference in genetic studies through genotype-directed deep-phenotyping.