David A. Hughes

The paper updates the metaboprep R package to support proteomics data, enhancing its utility for multi-omics preprocessing in epidemiological research.

This study identifies 400+ genetic loci associated with circulating metabolic traits and highlights pleiotropy and novel disease pathways.

This paper identifies 29 metabolites associated with genetic predisposition to higher BMI using a recall-by-genotype study design in young adults.

The paper describes the continental ancestry and population structure of non-white British individuals in the UK Biobank using reference populations and clustering methods.

metaboprep provides an R package for standardized pre-analysis processing and reporting of metabolomics data, enabling quality assessment and sample/metabolite selection.

The paper examines the genetic impact of an Ebola outbreak on a wild gorilla population, finding no change in genetic diversity but identifying six missense mutations potentially linked to survival.

The paper identifies the prevalence and phenotypic impact of loss of function mutations in the MC4R gene in a UK birth cohort, finding a 0.30% carrier rate with significant effects on body weight and BMI.

The paper identifies 31 host genetic loci influencing gut microbiome composition through GWAS and suggests causal effects in inflammatory diseases.

This paper introduces the Recall-by-Genotype study design to improve causal inference in genetic studies through genotype-directed deep-phenotyping.