A validated strategy to infer protein biomarkers from RNA-Seq by combining multiple mRNA splice variants and time-delay
Rasmus Magnusson, Olof Rundquist, Min Jung Kim, Sandra Hellberg, Chan Hyun Na, Mikael Benson, David Gómez-Cabrero, Ingrid Skelton Kockum, Jesper N. Tegner, Fredrik Piehl, Maja Jagodic, Johan Mellergård, Claudio Altafini, Jan Ernerudh, Maria Christina Jenmalm, , Mika Gustafsson
The paper develops a mathematical model combining mRNA splice variants and time-delay to predict protein abundance from RNA-Seq, improving biomarker discovery in immune diseases.
bioRxiv · Feb 21, 2020 · PreprintBioinformatics