Ingrid Skelton Kockum

Genomic impact of the second plague pandemic on three human populations

This study analyzes ancient DNA from three European sites to assess the genomic impact of the second plague pandemic, finding no strong positive selection but evidence of reduced long-range immigration post-pandemic.

Single-cell analysis suggests coordinated immune-cell redistribution between blood and cerebrospinal fluid in early multiple sclerosis

The paper uses single-cell sequencing to show coordinated immune-cell changes between blood and CSF in early MS, with CSF enrichment of memory T-cells and B-cells and depletion of cytotoxic populations.

Anoctamin-2-specific T Cells Link Epstein-Barr Virus to Multiple Sclerosis

CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

Unraveling genetic mysteries: phenotype-shaping profiles in chronic sarcoidosis

The paper identifies genetic variants associated with chronic sarcoidosis phenotypes using genome-wide association studies and functional analysis.

Dilated Virchow-Robin Spaces are a Marker for Arterial Disease in Multiple Sclerosis

This study investigates the clinical relevance of dilated Virchow-Robin spaces (VRS) as an imaging biomarker in multiple sclerosis, finding they correlate with vascular pathology rather than immune cell accumulation.

The genetic structure of Norway

This study examines the genetic structure of the Norwegian population, identifying two distinct genetic regions and highlighting the impact of geography on migration patterns and ancestry.

Profiling of small non-coding RNAs across cellular and biofluid compartments: implications for multiple sclerosis immunopathology

The paper profiles small non-coding RNAs in multiple compartments of MS patients and controls, identifying distinct sncRNA expression patterns in CSF and PBMCs that suggest organ-specific regulatory mechanisms.

A validated generally applicable approach using the systematic assessment of disease modules by GWAS reveals a multi-omic module strongly associated with risk factors in multiple sclerosis

The paper benchmarks disease module identification methods using GWAS and validates a multi-omic module strongly associated with multiple sclerosis risk factors.

A validated strategy to infer protein biomarkers from RNA-Seq by combining multiple mRNA splice variants and time-delay

The paper develops a mathematical model combining mRNA splice variants and time-delay to predict protein abundance from RNA-Seq, improving biomarker discovery in immune diseases.

Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire

This study identifies genetic risk loci for narcolepsy, showing enrichment in immune cells and suggesting autoimmune modulation via T cell receptor chains and influenza-A infection.