Fredrik Piehl

This paper uses 6-base sequencing to analyze DNA modifications in cerebrospinal fluid cell-free DNA, providing insights into neurodegenerative biology for liquid biopsy applications.

The paper uses single-cell sequencing to show coordinated immune-cell changes between blood and CSF in early MS, with CSF enrichment of memory T-cells and B-cells and depletion of cytotoxic populations.

This study identifies DNA methylation changes in cerebrospinal fluid cells from MS patients, linking them to immune regulatory alterations and implicating protocadherins in MS pathogenesis.

CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

This study investigates the clinical relevance of dilated Virchow-Robin spaces (VRS) as an imaging biomarker in multiple sclerosis, finding they correlate with vascular pathology rather than immune cell accumulation.

The paper profiles small non-coding RNAs in multiple compartments of MS patients and controls, identifying distinct sncRNA expression patterns in CSF and PBMCs that suggest organ-specific regulatory mechanisms.

This study identifies Gsta4 as a regulator of apoptosis in adult oligodendrocyte differentiation and remyelination, showing its role in modulating the Fas/Casp8/Bid mitochondrial axis.

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

This study uses diffusion tensor imaging and machine learning to predict brain age in schizophrenia and bipolar disorder patients, finding age overestimation in both groups compared to controls.

The paper develops a mathematical model combining mRNA splice variants and time-delay to predict protein abundance from RNA-Seq, improving biomarker discovery in immune diseases.

The paper reports a detailed genetic and genomic map of multiple sclerosis, identifying susceptibility genes in peripheral immune cells and brain-resident microglia.

The paper identifies low-frequency coding variants contributing to multiple sclerosis risk using a large case-control study.

This study identifies a polygenic link between blood lipids and amyotrophic lateral sclerosis, finding causal effects of LDL-C and TC on ALS risk.

The paper investigates the relationship between T-cell activation, HLA regulation, and smoking in the airways of multiple sclerosis patients.