Maria Vias

The paper identifies genomically unstable secretory cells in fallopian tubes of BRCA1/2 carriers using single-cell transcriptomics, linking them to replication stress and early cancer transformation.

The paper uses single cell mass cytometry to identify protein modules associated with carboplatin resistance and sensitivity in ovarian cancer models.

The paper generates and characterizes three new HGSOC cell lines that retain genomic and pathologic features of their parental tumors, providing models for studying chemoresistance.

The paper evaluates tools for estimating absolute copy numbers from shallow whole genome sequencing data and introduces an improved tool called Rascal.