Anna Piskorz

scUnique measures ongoing chromosomal instability from single-cell whole genome sequencing data by identifying recent copy number aberrations in phylogenetic trees.

The paper introduces a scalable method for profiling FFPE tissue microarrays using spatial single-cell transcriptomics, achieving subcellular resolution in human liver samples.

The paper optimizes the Xenium in situ sequencing protocol for spatial transcriptomics in Medicago truncatula roots and nodules, enabling high-resolution gene expression analysis in plant tissues.

The paper generates and characterizes three new HGSOC cell lines that retain genomic and pathologic features of their parental tumors, providing models for studying chemoresistance.

scAbsolute measures single-cell ploidy and replication status using single-cell DNA sequencing without prior knowledge of cell cycle phase.

FrenchFISH improves DNA copy number quantification from FISH images by using Poisson models, outperforming manual and automated methods in ovarian cancer tissue sections.

The paper shows that selecting short DNA fragments in plasma improves the detection of circulating tumour DNA by enriching mutated DNA, enabling identification of copy number alterations previously undetected.