Lance Wells

This study identifies an EZH2/TRIM28 epigenetic axis that regulates heparan sulfate remodeling and promotes melanoma metastasis.

This study shows that mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation through interactions with heparan sulfate proteoglycans.

This paper develops glycan-engineered alphavirus-like particles as HIV-1 fusion peptide immunogens, showing improved antibody responses and neutralization against multi-clade HIV-1.

This paper introduces WIN332, an engineered immunogen that elicits N332-glycan-independent V3-glycan antibodies in nonhuman primates after a single immunization.

This study shows that ALK3-BMP signaling in tongue mesenchyme is essential for taste papilla cell differentiation by regulating secretory proteins and Wnt/β-catenin activity.