Author

Zi Jie Lin

The Wistar InstituteORCID 0009-0004-1707-6471Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:non-human primate· 1

Frequent Co-Authors

Daniel W. KulpiD· 3 shared Jesper PalleseniD· 3 shared Amber KimiD· 2 shared Amelia EscolanoiD· 2 shared Beatrice H. HahniD· 2 shared Colby J. AgostinoiD· 2 shared David B. WeineriD· 2 shared George M. ShawiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Daniel W. KulpORCID

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Author profile →

3 papers

Recent·Most cited

Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination

Rumi Habib, Shahlo O. Solieva, Zi Jie Lin, Sukanya Ghosh, Kelly Bayruns, Maya Singh, Colby J. Agostino, Nicholas J. Tursi, Kirsten J. Sowers, Jinwei Huang, Ryan S. Roark, Mansi Purwar, Younghoon Park, Kasirajan Ayyanathan, Hui Li, , Daniel W. Kulp

The paper identifies frequent and genetically diverse CDRH3 topologies in the human antibody repertoire that can be targeted by vaccination to elicit broadly neutralizing antibodies.

Proceedings of the National Academy of Sciences · Apr 29, 2026Peer-reviewedImmunology

Machine learning enables de novo multi-epitope design of plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody

Andrew Nelson, Samuel E. Garfinkle, Zi Jie Lin, Joyce H. Park, Amber Kim, Kelly Bayruns, Madison E. McCanna, Kylie M. Konrath, Colby J. Agostino, Daniel W. Kulp, Audrey R. Odom John, Jesper Pallesen

The paper designs a multi-epitope immunogen for malaria using machine learning, demonstrating its ability to bind and orient three copies of the L9 antibody.

Proceedings of the National Academy of Sciences · Dec 3, 2025Peer-reviewedBiophysics

Rapid elicitation of a new class of neutralizing N332-glycan independent V3-glycan antibodies against HIV-1 in nonhuman primates.

Ignacio Relaño-Rodríguez, Jianqiu Du, Zi Jie Lin, Margaret Kerwin, Marta Tarquis-Medina, Eduardo Urbano, Jiayan Cui, Meagan Watkins, Peng Zhao, Rumi Habib, Sukanya Ghosh, Joyce H. Park, Caroline Boroughs, Agnes A. Walsh, Mariane B. Melo, , Amelia Escolano

This paper introduces WIN332, an engineered immunogen that elicits N332-glycan-independent V3-glycan antibodies in nonhuman primates after a single immunization.

bioRxiv · Sep 4, 2025 · PreprintImmunology