Author

Patrizia Porazzi

Abramson Cancer CenterORCID 0000-0002-1372-7482Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

Federico StellaiD· 2 shared Luca ParuzzoiD· 2 shared Marco RuellaiD· 2 shared Vinodh PillaiiD· 2 shared Adam BaggiD· 1 shared Adam Barsouk· 1 shared Alain H. RookiD· 1 shared Alberto CarturaniD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersCancer Biology

Federico StellaORCID

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Author profile →

3 papers

Recent·Most cited

The ancestral haplotype of P2RX5 yields a B-cell surface marker and a multi-lineage immunotherapy target

Zhiwei Ang, Annette Castro, Luca Paruzzo, Carolin Schimdt, Zainul S. Hasanali, Katharina E. Hayer, Federico Stella, Samantha S. Soldan, Manuel Torres-Diz, Christopher Kwok, Patricia King Sainos, Kayla W. Ji, Patrick J. Krohl, Justyn Fine, Priyanka D. Sehgal, , Andrei Thomas‐Tikhonenko

The paper identifies P2RX5 as a new B-cell surface marker and multi-lineage immunotherapy target, showing its expression in B-cell malignancies and T-cell leukemia, and demonstrating the efficacy of P2RX5-directed therapies.

bioRxiv · Jan 26, 2026 · PreprintCancer Biology

Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T cell therapies

Alberto Carturan, Mathew G. Angelos, Puneeth Guruprasad, Ruchi P. Patel, Raymone Pajarillo, Andrew Evan Lee, Yunlin Zhang, Wei Xie, Jesse L. Rodriguez, Jaryse Harris, Pooja Devi, Olabisi I. Afolayan-Oloye, Jason Xu, Jonathan H. Sussman, Omar Elghawy, , Marco Ruella

This paper develops anti-CD2 CAR T-cells that overcome fratricide and improve efficacy by incorporating a PD-1:CD2 switch receptor to restore CD2 signaling.

Blood · Jan 5, 2026Peer-reviewedCancer Biology

Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

Luca Pagliaroli, Patrizia Porazzi, Alyxandra T. Curtis, Chiara Scopa, Harald M. M. Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A. Welsh, Sarah R. Offley, Connor A. Ott, Bruno Calabretta, Samantha A. Brugmann, Gijs W.E. Santen, Marco Trizzino

This study shows that failure to switch from ARID1A-BAF to ARID1B-BAF in patient-derived cells impairs neural crest formation in Coffin-Siris syndrome.

Nature Communications · Nov 9, 2021Peer-reviewedGenomics