Harald M. M. Mikkers

This study uses hiPSC-derived retinal organoids to show that ABCA4 loss in photoreceptors disrupts glial cell homeostasis, suggesting a role for glial cells in Stargardt disease progression.

The paper shows ARID1A-haploinsufficiency impairs EMT in CNCC specification by disrupting ARID1A-BAF binding at EMT enhancers, which affects ZIC2 occupancy and leads to aberrant neuronal gene activation.

This study shows that failure to switch from ARID1A-BAF to ARID1B-BAF in patient-derived cells impairs neural crest formation in Coffin-Siris syndrome.