Marco Donia

This study profiles the proteomics and phosphoproteomics of melanoma cells under T cell attack to identify immune checkpoint targets and therapeutic vulnerabilities.

The paper shows that a short IFN-γ pulse induces a long-term proteomic signature in melanoma cells, challenging assumptions about cytokine signaling duration.

This study examines how checkpoint receptors in circulating γδ T cells correlate with cancer immunotherapy outcomes, identifying potential prognostic markers and therapeutic targets.

The paper demonstrates the use of double-emulsion droplet technology to analyze single-cell effector function in adoptive cell therapy, enabling high-resolution study of cell-cell interactions and functional heterogeneity.