Ilaria Piga

The proteomics and phosphoproteomics landscape of melanoma under T cell attack

This study profiles the proteomics and phosphoproteomics of melanoma cells under T cell attack to identify immune checkpoint targets and therapeutic vulnerabilities.

Acute IFN-γ elicits long-term proteomic IFN-γ signature in melanoma cells

The paper shows that a short IFN-γ pulse induces a long-term proteomic signature in melanoma cells, challenging assumptions about cytokine signaling duration.

The Human Cell Line Phosphoproteome Atlas: A Deep Empirical Resource Revealing Kinase Activity Landscapes

The paper presents a comprehensive human phosphoproteome atlas with over 200,000 phosphosites, improving phosphoproteomics speed and accuracy, and identifies kinase activity patterns linked to drug sensitivity.

Organoid-based modeling of platinum resistance identifies KRT17 as both a response mediator and biomarker for targeted therapy in ovarian cancer

This study identifies KRT17 as a mediator of platinum resistance and a biomarker for targeted therapy in ovarian cancer using organoid models and clinical data.

Systematic optimization of automated phosphopeptide enrichment for high-sensitivity phosphoproteomics

The paper optimizes automated phosphopeptide enrichment to improve phosphoproteome coverage and sensitivity in low-input samples using LC-MS/MS.