Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol
Fazhi Yu, Qin Zhou, Tong Zhou, Yijia Xie, Peng Zhang, Wei He, Weiqiang Yu, Aoxing Cheng, Hanyuan Liu, Qingfa Wu, Xiaopeng Ma, Jing Song Guo, Ying Zhou, Jue Shi, Zhenye Yang
This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.
bioRxiv · Jul 8, 2024 · PreprintCancer Biology