Jue Shi

This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.

The paper uses single-cell imaging and mathematical modeling to analyze p53 pathway dynamics in response to chemotherapeutics, identifying novel feedback motifs and their role in context-specific signaling responses.

This study identifies bimodal p53 dynamics as a mechanism modulating resistance to DNA damaging chemotherapy, showing that ATM expression determines sensitivity and that inhibiting Mdm2 and Wip1 can sensitize resistant cells.