Bilateral regulation of EGFR activity and local PI dynamics observed with superresolution microscopy
Mitsuhiro Abe, Masataka Yanagawa, Michio Hiroshima…·Yasushi Sako
This study uses super-resolution microscopy to show that EGFR and PI(4,5)P2 nanodomains coaggregate before EGF stimulation, and their interaction is regulated by phospholipase Cγ and PI(4,5)P2 levels.