Mark N. Gillespie

The paper uses MOA-seq to map transcription factor occupancy in hypoxia-treated human endothelial cells, identifying thousands of hypoxia-responsive sites and clustering them into HIF1A-associated and independent TF groups.

The paper identifies thousands of alternative splicing events in human vascular endothelial cells under hypoxia, revealing a more complex and dynamic transcriptional response than conventional RNA-seq suggests.

This study shows that oxidative injury to mitochondrial DNA contributes to acute and chronic lung injury, and that targeting OGG1 can mitigate this damage.

The paper identifies LG4 enhancers that physically interact with gene promoters via G4:G4 DNA structures and links SNPs in these enhancers to CF lung disease severity.