Viktor M. Pastukh

The Cistrome Response to Hypoxia in Human Umbilical Vein Endothelial Cells

The paper uses MOA-seq to map transcription factor occupancy in hypoxia-treated human endothelial cells, identifying thousands of hypoxia-responsive sites and clustering them into HIF1A-associated and independent TF groups.

Analysis of alternative splicing uncovers a vastly expanded transcriptomic response to hypoxia in human vascular endothelial cells

The paper identifies thousands of alternative splicing events in human vascular endothelial cells under hypoxia, revealing a more complex and dynamic transcriptional response than conventional RNA-seq suggests.

Oxidative Injury to Lung Mitochondrial DNA is a Key Contributorfor the Development of Chemical Lung Injury

This study shows that oxidative injury to mitochondrial DNA contributes to acute and chronic lung injury, and that targeting OGG1 can mitigate this damage.